注册本刊作者作者投稿查稿
专家远程审稿编辑在线审稿
编务办公专区主编办公专区
下载文档
工作动态
联系方式
发行周期:
月刊
主管单位:
上海市卫生健康委员会
主办单位:
上海市医学会
编辑出版:
《上海医学》编辑部
联系地址:
上海市北京西路1623号
邮编:
200040
电话:
021-62178606
传真:
021-62178606
邮箱:
smasmj@shsma.org.cn
ISSN:
ISSN0253-9934
CN:
CN31-1366/R
收款账号:
1001255309008900719
账户名:
上海市医学会
开户行:
工商银行上海市静安寺支行
友情链接

当前位置：首页 > 过刊浏览->2010年第12期

右美托咪定用于神经外科高血压病人全麻拔管期间的临床研究
Clinical Research of dexmedetomidine on the reaction during the extubation period of general anesthesia in hypertension patients with neurosurgery

浏览(2549) 下载(0)

DOI:
作者:
尤克强
YOU Keqiang
作者单位:
江苏省连云港市第一人民医院麻醉科
Department of Anesthesiology,the Fist Hospital of Lingyungang,Lingyungang
关键词:
右美托咪定； 神经外科； 高血压
Dexmedetomidine;Neurosurgery;Hypertension
摘要:
目的 探讨右美托咪定用于高血压病人全麻拔管期的有效性和安全性。方法 选择44例行神经外科手术的高血压患者，随即分成右美托咪（D）组和生理盐水（N）组，每组22例，分别于手术结束前30min给药，记录诱导前，注药前．拔管时、拔管后1 min、5min、l0 min时的平均动脉压、心率，以及疼痛视觉模拟评分。结果 与麻醉前比较，D组在各时间点MAP、HR无显著性差异，较为平稳。N组拔管时、拔管后1 min、5 min、l0 min时的MAP、HR均比注药前和D组同期有显著差异（P< 0.05）。D组VAS评分明显低于N组（P< 0.05）。两组苏醒时间无显著性差异。结论 右美托咪定用于神经外科高血压病人全麻拔管，有效使呼吸、循环稳定，全面减少拔管期病人的不良反应，且不影响病人清醒，是麻醉医生的新选择。
Objective To investigate the effectiveness and safety of dexmedetomidine on the reaction during the extubation period of general anesthesia in hypertension patients with neurosurgery. Methods 44 hypertension patients with neurosurgery were randomly divided into two groups, dexmedetomidine group(D group n=22) and saline group(C group n=22),drugs were administrated at 30 min before the operation completed. mean artery pressure（MAP）,heart rate(HR) and visual analogue scale(VAS) were recorded before anesthesia,before drugs injection,during extubation and at 1min,5min,10min after extubation Results In D group,MAP and HR were no significant differences at each time point compared to that of pre- anesthesia.In C group, ,MAP and HR were significant differences during and after extubation compared to that of pre- injection or D group. The VAS scores in D group was significantly lower compared to that of N group. There was a no significant difference in the awakening time between two groups. Conclusions Dexmedetomidine is profit for the stabilization of respiration and circulation, which inhibite adverse reaction when extubation,but no affect on the awakening. In hypertension patients with neurosurgery ,the administration of dexmedetomidine during the extubation period of general anesthesia is a perfect procedure.

 

主管单位：上海市卫生健康委员会  主办单位：上海市医学会
©2024《上海医学》编辑部 沪ICP备09078599号
您是本站第26556618名访问者
网站管理