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肥胖特殊亚型分布及影响因素的横断面社区调查
Cross-sectional study on the distribution and risk factors of the special subgroups of obesity in community based-subjects

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DOI:
作者:
范晶
Fan Jing
作者单位:
重庆医科大学附属第一医院急诊科
The First Affiliated Hospital，Chongqing Medical University
关键词:
肥胖; 正常体重代谢性肥胖; 代谢正常肥胖; 调查; 危险因素
Obesity; Metabolically obese normal-weight; Metabolically normal obese; Survey; Risk factors
摘要:
目的 了解重庆大学社区自然人群中肥胖两种特殊亚型：正常体重代谢性肥胖（MONW）、代谢正常肥胖（MNO）分布情况及其影响因素。方法 调查于2008年3月至6月完成。以重庆大学社区20岁以上自然人群为调查对象，共3543人（男性占56.20%，女性占43.80%，年龄分布于22-95岁，平均年龄58.32+0.21岁）。内容包括：问卷调查、体格检查及相关生化指标的检测等。结果 在调查人群中，MONW患病率4.90%，MNO患病率5.05%；在体重正常人群中，MONW患者占13.15%，在肥胖人群中MNO占14.15%。随年龄增长MONW的患病率不断增长，而在总人群和男性人群中MNO患病率随年龄的增长逐渐下降，但在女性人群中，MNO的患病高峰在中年人群（6.17%），60岁以后患病率明显下降。经Logistic回归分析显示：MONW的发生与高龄、既往吸烟、目前吸烟、饮酒史、糖尿病（DM）家族史相关；而MNO的发生与青年、中年、腰围、少至中量运动、高血压（HBP）家族史相关。结论 在人群中，MONW和MNO这两种肥胖亚型普遍存在，可通过人口学资料、病史、生活方式等简易指标筛查高危人群，早期识别及干预对于预防MONW患者发生心血管代谢事件有重要意义，而MNO人群的识别，对于在肥胖人群中根据特殊的亚型而制定不同的干预措施有重要意义。
Objective To investigate the prevalence of the subgroups of obesity which was known as metabolically obese normal-weight(MONW) and metabolically normal obese(MNO), and the influencing factors in Chongqing university community. Methods 3543 subjects aged 22-95 years old [56.20% males and 43.80% females, mean age (58.32+0.21)] between march and June 2008 were recruited in community of Chongqing university. Questionnaire survey, Physical examination and biochemical test were detected and analyzed. Results Among all subjects we studied, the prevalence of MONW and MNO was 4.90% and 5.09%; 13.15% of normal weight subjects were metabolically abnormal, whereas 14.15% of obese subjects were metabolically healthy. The prevalence of MONW was increased with aging either in men or in women, while the prevalence of MNO was decreased with aging in men. But the highest level of the prevalence of MNO in women was in middle-aged group (6.17%), and decreased after 60 years old. Among the factors entered into multivariable logistic regression models, older men、former smoking、current smoking、alcohol intake history、family history of type 2 diabetes mellitus were the related factors for MONW, while young men、middle aged men、waist circumference、slightly physical activity、moderate physical activity and family history of hypertension were the related factors for MNO. Conclusion The special subgroups of obesity MONW and MNO were common in Chongqing university community. Some simple factors such as: demography information、life style、diseases and family history may help to identify the person who had the high risk to have MONW, to diagnose and treat in earlier time was important to prevent the cardiometabolic disease, and the identification of the MNO subgroup was important to discriminate the different treat way among the different subgroups of obesity.

 

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