注册本刊作者作者投稿查稿
专家远程审稿编辑在线审稿
编务办公专区主编办公专区
下载文档
工作动态
联系方式
发行周期:
月刊
主管单位:
上海市卫生健康委员会
主办单位:
上海市医学会
编辑出版:
《上海医学》编辑部
联系地址:
上海市北京西路1623号
邮编:
200040
电话:
021-62178606
传真:
021-62178606
邮箱:
smasmj@shsma.org.cn
ISSN:
ISSN0253-9934
CN:
CN31-1366/R
收款账号:
1001255309008900719
账户名:
上海市医学会
开户行:
工商银行上海市静安寺支行
友情链接

当前位置：首页 > 过刊浏览->2011年第5期

Hedgehog信号通路活化在结直肠病变的意义

浏览(2605) 下载(0)

DOI:
作者:
翁子毅1 ,子树明1, 杨明1 ,崔龙1 ,于恩达2
WENG ZIYI,ZI SHUMING,YANG MING,CUI LONG,YU ENDA
作者单位:
1上海交通大学医学院附属新华医院肛肠外科 2第二军医大学附属长海医院肛肠外科
1Department of Colorectal Surgery, Xinhua Hospital Shanghai Jiangtong University School of Medicine 200092 2Department of Colorectal Surgery, Changhai Hospital of Shanghai The Second Military Medical University 200433
关键词:
SHH， PTCH，SFRP1，结直肠癌，结直肠息肉
摘要:
目的 探讨Hedgehog（Hh）信号通路蛋白表达在结直肠病变的意义。方法：采用免疫组化技术检测人正常结直肠黏膜、结直肠息肉及结直肠癌等组织中Hh 信号通路蛋白SHH、PTCH和SFRP1的表达，并对数据进行统计分析。结果：正常结直肠组织中，SHH和PTCH蛋白不表达或轻度表达，SFRP1蛋白在细胞浆和间质细胞轻度表达。结直肠息肉中，SHH轻度表达，PTCH和SFRP1不表达或轻中度表达。结直肠癌的SHH、PTCH和SFRP1大多呈高度表达。不同结直肠病变的SHH（p=0.000）、PTCH（p=0.001）和SFRP1（p=0.043）蛋白表达的差异有统计学意义。结论： Hh信号通路蛋白在正常结直肠黏膜几乎不表达，在结直肠息肉有不同程度表达，在结直肠癌大多高度表达，提示其逐步量变与结直肠恶性病变的进程有关。
Objective: To study the effect of hedgehog (Hh) signal pathway in colorectal disease. Methods: Detect the expression of Hh signal pathway protein SHH, PTCH and SFRP1 in human colorectal polyps, colorectal cancer and normal colorectal mucosa specimens by immunohistochemistry and make statistic analysis. Results: In normal colorectal mucosa, SHH and PTCH were absent or slightly staining, SFRP1 was slightly staining in cytoplasm and in interstitial cells. In colorectal polyps, SHH was detected as slightly staining in cytoplasm, while PTCH and SFRP1 showed absent or slightly/medium staining. In colorectal cancer, SHH, PTCH and SFRP1 were all strongly staining. The expression of SHH（p=0.000）、PTCH（p=0.001）and SFRP1（p=0.043）were significantly different in different colorectal diseases. Conclusion: Hh signal pathway proteins were inactivation in normal colorectal mucosa, slight expression in colorectal polyps，but most highly activated in colorectal cancer. These suggest that the quantitative changes of the proteins are related to the progress of colorectal malignance. [Key words] SHH, PTCH, SFRP1, colorectal cancer, colorectal polyps

 

主管单位：上海市卫生健康委员会  主办单位：上海市医学会
©2024《上海医学》编辑部 沪ICP备09078599号
您是本站第26557051名访问者
网站管理