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右美托咪定与丙泊酚用于子痫患者镇静的效果比较
Comparison between dexmedetomidine and propofol for sedation of eclampsia patients

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DOI:
作者:
王洪亮
WANG Hong-liang
作者单位:
哈尔滨医科大学附属第二医院
Department of Intensive Care Unit, the Second Affiliated Hospital of Harbin Medical University
关键词:
右美托咪定；丙泊酚；子痫；重症医学科
Dexmedetomidine; Propofol; Eclampsia; Intensive care unit
摘要:
目的 比较右美托咪定与丙泊酚对子痫患者镇静的临床效果和安全性。方法 需镇静的子痫患者随机分为两组：右美托咪定组(D组，n=20)和丙泊酚组(P组，n=20)。D组：给予右美托咪定负荷量1ug/kg•h静脉泵注20min，根据不同镇静程度以0.3-0.7ug/kg•h持续静脉泵入；P组：首先静脉推注1mg/kg丙泊酚进行镇静诱导，亦根据不同镇静程度维持剂量为0.5-4.0mg/kg•h。观察两组患者的心率、血压、降压药物用量、住ICU时间等。结果 与P组相比，D组患者心率在0-24h明显减慢(p <0.05)，而24-72h心率变化无明显差别(p >0.05)；与P组相比，D组患者降压药物的用量减少(p <0.05)，住ICU时间缩短。结论 右美托咪定用于子痫患者镇静是安全有效的，而且能够降低降压药物的用量和缩短住ICU时间。
Objective To compare the effectiveness and safety of dexmedetomidine and propofol for the sedation of eclampsia patients admitted to our intensive care unit (ICU). Methods Forty eclampsia patients requiring termination of pregnancy were randomized in to two groups to receive either dexmedetomidine or propofol.The dexmedetomidine group (Group D, n =20) received a loading dose of 1 ug/kg•h for twenty minutes, followed by continuous infusion at 0.3-0.7ug/kg•h. The propofol group (Group P, n =20) loading dose was 1mg/kg, followed by continuous infusion at 0.5-4.0mg/kg•h. Heart rate, blood pressure, anti-hypertension drug dosage and duration in ICU were monitored and recorded. Results Compared with Group P, the heart rates in Group D were significantly slower in 0-24h (p <0.05), while therewere no differences during 24-72h (p> 0.05); Moreover, the demand for antihypertensive medicine and duration of ICU stay was less in Group D (p <0.05). Conclusion Dexmedetomidine for the sedation of eclampsia patients is safe and effective whice reduces the demand for antihypertensive medicine and duration of ICU stay.

 

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