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前列地尔联合羟苯磺酸钙治疗心肾综合征的临床研究（返修后）
Clinical Study of Alprostadil combined with Calcium Dobesilate for treatment of Cardiorenal syndrome

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DOI:
作者:
邹武松,顾晔,成忠,李论,吴婕
ZOU Wu-song,GU Ye,CHENG Zhong,LI Lun,WU Jie
作者单位:
武汉市普爱医院心内科
Department of Cardiology, Puai Hospital, Wuhan
关键词:
前列地尔,羟苯磺酸钙,心肾综合征
Alprostadil,Calcium Dobesilate ,Cardiorenal syndrome
摘要:
目的 前瞻性观察前列地尔联合羟苯磺酸钙对心肾综合征患者心、肾功能的影响。方法 将78例心肾综合征患者随机分成两组，对照组采用常规慢性心力衰竭治疗，治疗组在常规治疗基础上加用前列地尔针剂及羟苯磺酸钙胶囊治疗。检测治疗前后两组6分钟步行试验的步行距离(6MWD)、左心室射血分数（LVEF）、脑钠肽(BNP)、肌酐清除率(CCR)及尿微量白蛋白/肌酐比值(ACR)。结果 与对照组相比，治疗组6MWD、LVEF、CCR明显提高，BNP、ACR显著下降，两组比较有统计学意义（P<0.01）。结论前列地尔联合羟苯磺酸钙能显著改善心肾综合征患者的心、肾功能。
Objective: To evaluate the effects of Alprostadil combined with Calcium Dobesilate on Cardiorenal function in patients with Cardiorenal syndrome. Methods: 78 patients with Cardiorenal syndrome were randomly divided into control group and treatment group. Control group using conventional therapy of chronic heart failure, treatment group were treated by Alprostadil combined with Calcium Dobesilate in regular basis. All patients underwent six-minute walking test, and six-minute walking distance(6MWD)、left ventricular ejection fraction （LVEF）、Brain Natriuretic Peptide(BNP)、creatinine clearance rate(CCR) and albumin/creatinine ratio (ACR) were recorded before and after the treatment. Results: Compared with the control group, 6MWD、LVEF and CCR were significantly improved in the treatment group, BNP and ACR were decreased sharply. There were significant differences among 2 groups(P<0.01). Conlusion: The Cardiorenal function will be greatly ameliorated by Alprostadil combined with Calcium Dobesilate for patients with Cardiorenal syndrome.

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