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非小细胞肺癌血管内皮Nestin表达与临床病理指标及预后的相关性
Vascular endothelial expression of Nestin in association with clinicopathological factors and prognosis in non-small cell lung cancer

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DOI:
作者:
钱嘉琳，杨晓华，冯久贤，沙慧芳，韩宝惠
QIAN Jialin,YANG Xiaohua,FENG Jiuxian,SHA Huifang,
作者单位:
钱嘉琳 上海交通大学附属胸科医院肺内科 杨晓华 上海交通大学附属胸科医院基础研究室 冯久贤 上海交通大学附属胸科医院基础研究室 沙慧芳 上海交通大学附属胸科医院基础研究室 韩宝惠 上海交通大学附属胸科医院肺内科
QIAN Jialin，Department of pulmonary medicine, Shanghai Chest hospital, Shanghai Jiaotong University YANG Xiaohua，Basic research laboratory, Shanghai Chest hospital, Shanghai Jiaotong University FENG Jiuxian，Basic research laboratory, Shanghai Chest hospital, Shanghai Jiaotong University SHA Huifang，Basic research laboratory, Shanghai Chest hospital, Shanghai Jiaotong University HAN Baohui，Department of pulmonary medicine, Shanghai Chest hospital, Shanghai Jiaotong University
关键词:
非小细胞肺癌；Nestin；微血管密度；预后
Non-small cell lung cancer；Nestin；Microvessel density；Prognosis
摘要:
目的 Nestin是一类新型的肿瘤新生血管内皮细胞标记物。本研究拟检测非小细胞肺癌组织血管内皮中 Nestin的表达，并分析其与非小细胞肺癌患者临床病理指标及预后的相关性。方法 采用免疫组化方法检测非小细胞肺癌组织中 Nestin表达。Mann-Whitney U检验与Kruskal-Wallis法检验Nestin标记微血管密度与临床病理指标的关系，Kaplan-Meier生存曲线计算无疾病生存期和生存时间，log-rank进行差异检验，采用Cox分析评估各指标与患者生存之间的关系。结果 135例非小细胞肺癌组织中，Nestin主要表达于小血管内皮细胞。Nestin标记微血管密度与肺癌患者的病理类型、病理分期、T分期、N分期及血管侵犯相关，微血管密度较高组患者无疾病生存期劣于较低组，Nestin标记微血管密度是影响生存的独立因素。 结论 非小细胞肺癌血管内皮Nestin表达与肿瘤血管新生、转移及预后密切相关。
Objective Nestin is a new marker of newly formed vessels in malignant tumors. The aim of this study is to detect the expression of Nestin in vascular endothelial cells and to evaluate its implication for the clinicopathological factors and prognosis in patients with non-small cell lung cancer. Methods Nestin expression was detected by immunohistochemical staining in 135 cases of non-small cell lung cancer patients. Correlations between Microvessel desity evaluated by Nestin and clinicopathological factors were analyzed using the Mann-Whitney U test and Kruskal-Wallis test. The Kaplan-Meier method was used to calculate the disease-free survival and overall survival rate, and the difference in survival curves was evaluated using a Log-rank test. Univariate and multivariate analysis was carried out using the Cox proportional-hazard model. Results Nestin mainly expressed in endothelial cells of small vessels. Microvessel desity evaluated by Nestin was related to histologic type, pathological stages, T stage, N stage and vascular invasion. The disease-free survival was worse in the highly nestin-positive MVD group. MVD evaluated by Nestin was the independent prognostic factor in these patients. Conclusion Vascular endothelial expression of Nestin was closely related to tumor angiogenesis, metastasis and prognosis in patients with non-small cell lung cancer.

 

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