注册本刊作者作者投稿查稿
专家远程审稿编辑在线审稿
编务办公专区主编办公专区
下载文档
工作动态
联系方式
发行周期:
月刊
主管单位:
上海市卫生健康委员会
主办单位:
上海市医学会
编辑出版:
《上海医学》编辑部
联系地址:
上海市北京西路1623号
邮编:
200040
电话:
021-62178606
传真:
021-62178606
邮箱:
smasmj@shsma.org.cn
ISSN:
ISSN0253-9934
CN:
CN31-1366/R
收款账号:
1001255309008900719
账户名:
上海市医学会
开户行:
工商银行上海市静安寺支行
友情链接

当前位置：首页 > 过刊浏览->2012年第10期

小剂量艾司洛尔持续输注对围术期肌钙蛋白I表达的影响
Influence of low dose Esmolol infusion on the serum concentration of troponin I

浏览(2595) 下载(0)

DOI:
作者:
沈亮, 陆志俊, 丁雯 ,李永兴, 罗艳, 于布为
Shen Liang，LU Zhi-jun，Li Yongxing，Ding W
作者单位:
瑞金医院卢湾分院
Luwan Branch of Ruijin Hospital，Shanghai Jiaotong University School of Medicine
关键词:
艾司洛尔 老年患者 肌钙蛋白I
Esmolol，Aged patients，TroponinI
摘要:
【摘要】目的 观察围术期剂量艾司洛尔持续输注，对老年患者肌钙蛋白I表达的影响。方法 择期行胃、肠道手术的老年患者120名（55-75岁），随机分为艾司洛尔组（E组）和对照组（C组）(n=60)。艾司洛尔组从麻醉诱导前5min开始,持续输注艾司洛尔20ug/kg/min，C组则以相同的速度输注生理盐水。观察患者在入室后(T1)、诱导前(T2)、诱导后3分钟(T3)、插管后即刻(T4)、插管后3min(T5)、划皮前(T6)、划皮后3分钟(T7)、探腹前(T8)、探腹后(T9)、手术结束时(T10)、拔管前(T11)、拔管后3分钟(T12)的心率（HR）和平均动脉压（MAP）的变化。患者术前、手术结束时、术后24h测定血清肌钙蛋白I的浓度。结果 C组患者在插管后、划皮后、探腹后的HR明显加快（P<0.05）；而E组患者的HR没有显著增加。插管后和探腹后，两组患者的MAP均显著升高（P<0.05）；划皮后，C组患者的MAP升高明显（P<0.05），而E组变化不大（P>0.05）。两组患者的肌钙蛋白I值在各时间点之间比较均无差异（P>0.05）。 结论：术中持续小剂量艾司洛尔输注有助于维持老年患者的血流动力学稳定性，但不影响肌钙蛋白I的表达。
【Abstract】 Objective: To observe the effect of low dose Esmolol infusion during operation on the serum concentretion of cardiac troponinI. Method: 120 patients undergoing elective digestive tract operations were randomly divided into two groups: Esmolol Group (E) received continuous infusion with esmolol 20ug/kg/min 5min before induction; Control Group (C), received saline instead of esmolol. Patirents’ HR and MAP were recorded at the points as following: Base line (T1) 、before induction(T2)、3min after induction(T3)、 immediate after intubation(T4)、3min after intubation(T5)、before incision(T6)、3min after incision(T7)、before abdominal exploration (T8)、abdominal exploration (T9) 、end of the surgery (T10)、before extubation (T11)、3min after extubation (T12). The expression of serum cardiac troponinI was examined before surgery、at the end of surgery and 24h after surgery。 Results: 3 min after intubation, incision and abdominal exploration, patients’ HR were significantly increased in C group（P<0.05）, but not in E group. 3min after intubation and abdominal exploration, patients’ MAP were elevated in both groups（P<0.05）. Patients of C group, their MAP were significantly increased 3 min after incision（P<0.05）, but not in E group. There were no difference on the serum concentration of troponinI between those two groups on either time points（P>0.05）. Conclusion: Low dose esmolol continuously infusion during the surgery is helpful for the cardiovascular stability, however without effects on the serum concentration of troponinI. 【Key words】 Esmolol，Aged patients，TroponinI

 

主管单位：上海市卫生健康委员会  主办单位：上海市医学会
©2024《上海医学》编辑部 沪ICP备09078599号
您是本站第26557346名访问者
网站管理