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上海市卫生健康委员会
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慢性肾脏病住院患者亚临床甲状腺功能减退症的调查研究
Investigation of subclinical hypothyroidism in hospitalized patients with chronic kidney disease

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DOI:
作者:
黄燕萍，毛佩菊，奚敏慧
HUANG Yanping, MAO Peijv, XI Minhui
作者单位:
上海市长宁区中心医院肾脏科
Department of Nephrology, the Changning Center Hospital, Shanghai
关键词:
慢性肾脏病 亚临床甲状腺功能减退症 患病率
chronic kidney disease，subclinical hypothyroidism，prevalence
摘要:
目的：调查慢性肾脏病住院患者亚临床甲状腺功能减退症的患病情况，以提高改善慢性肾脏病患者生活质量。方法：对我院肾脏科住院的CKD患者收集一般资料，检测肾脏损伤指标、FT3、FT4、TSH及血脂、白蛋白等生化指标。结果：450例CKD住院患者中，男性217例，女性233例，平均年龄（70.3±15.1）岁。亚临床甲状腺功能减退症患病率8.4%，CKD1-5期中患病率分别为6.3%、5.0%、10.8%、21.9%、9.7%。亚临床甲状腺功能减退症患者平均年龄(66.2±16.5)岁，TSH平均(8.75±5.08) mIU/L，MDRD-GFR平均(54.2±38.0) ml/min/1.73m2。亚临床甲状腺功能减退症组MDRD-GFR低于甲状腺功能正常组，两组间差异有统计学意义（P<0.05）。随着肾功能减退，CKD患者罹患亚临床甲状腺功能减退症的危险性增加。结论：慢性肾脏病患者中亚临床甲状腺功能减退症患病率高，尤其是在肾功能减退患者。
Objective The prevalence of subclinic hypothyroidism in hospitalized patients with chronic kidney disease is not well defined. Methods We studied 450 cases of inpatients with chronic kidney disease who were tested with serum creatinine, uric acid, blood routine test, lipids, triiodothyronine, thyroxine and thyroid stimulating hormone. Results A total of 450 hospitalized patients with CKD were enrolled during the observation period, with M/F ratio of 217/233 and mean age of (70.3±15.1) years. The prevalence of subclinical hypothyroidism with CKD was 8.4%. The percentage of these inpatients in CKD stage 1-5 was approximately 6.3%, 5.0%, 10.8%, 21.9% and 9.7% respectively. The mean age of the subclinical hypothyroidism patients was (66.2±16.5)岁.The mean of TSH was (8.75±5.08)mIU/L and the average of eGFR was (54.2±38.0) ml/min/1.73m2. The logistic regression model showed that the risk factors of subclinical hypothyroidism was decreased renal function. Conclusions The prevalence of subclinical hypothyroidism with CKD inpatients is 8.4%. And it is highly prevalent in inpatients with renal dysfunction.

 

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