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实时超声弹性成像对梗阻性黄疸的初步定量化研究
Preliminary quantitative study on obstructive jaundice by real-time ultrasound elastography

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DOI:
作者:
李银侠*，洪峻峰*，郭佳?，梁丽琼，谭碧波，马骏
Li Yinxia, Hong Junfeng, Guo Jia，et al
作者单位:
上海市第二军医大学附属东方肝胆外科医院超声科
Department of Ultrasonography, Second Military Medical University Affiliated Eastern Hepatobiliary Surgery Hospital
关键词:
超声弹性成像；梗阻性黄疸；应变均值；蓝色领域百分比
Real-time ultrasound elastography; Obstructive jaundice; MEAN; %AREA
摘要:
摘 要 目的 探讨实时超声弹性成像技术搭载的组织弥散定量分析功能用于梗阻性黄疸的初步应用价值。 方法 选择梗阻性黄疸患者86例，根据临床总胆红素指标分为轻、中、重度黄疸三个级别，另设对照组35例为无黄疸或隐形黄疸患者，应用超声弹性成像的组织弥散定量分析功能，测量肝脏的应变均值（MEAN）及蓝色领域百分比（%AREA）。 结果 对照组与研究组、对照组与各级黄疸组之间比较MEAN及%AREA差异均有统计学意义，黄疸程度与应变均值存在负相关关系(Spearman相关系数r=-0.5, P<0.000)，与蓝色领域百分比存在正相关关系(Spearman相关系数r= 0.5，P<0.000)。 结论 实时超声弹性成像的弥散定量分析功能可反映梗阻性黄疸的程度，MENA及%AREA值可做为评估梗阻性黄疸程度的定量化参考指标，与传统超声检查方法相结合，有望成为全面反映梗阻部位及黄疸程度的超声检查新方法。 关键词 超声弹性成像；梗阻性黄疸；应变均值；蓝色领域百分比
Abstract Objective To investigate the preliminary quantitative application value of obstructive jaundice by real-time ultrasound elastography with Strain Histogram Measurement Function. Methods 86 patients with obstructive jaundice were enrolled and divided into mild、 moderate 、high levels of jaundice according to the clinical total bilirubin (TB) index , besides, 35 patients without jaundice or with invisible jaundice as control group. ALL of them were underwent real-time ultrasound elastography and the liver MEAN and blue area percentage (% AREA) were measured by Strain Histogram Measurement Function. Results The liver MEAN and %AREA had statistical differences among the control group 、the research group and all levels of jaundice； a negative correlation between the MEAN and the jaundice levels( Spearman, s correlation coefficient r= -0.5, P < 0.000) and a positive correlation between the %AREA and the jaundice levels( Spearman, s correlation coefficient r=0.5, P < 0.000) were detected. Conclusion Real-time ultrasound elastography with Strain Histogram Measurement Function could reflect the degree of obstructive jaundice, the MEAN and %AREA can be used as quantitative reference index of evaluating obstructive jaundice degree, together with traditional ultrasonic method, can be expected to become a new ultrasonic method which can completely reflect both the obstruction part and jaundice degree.

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