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芬太尼伍用地佐辛对全麻诱导时依托咪酯致肌阵挛的影响

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DOI:
作者:
蔡晗
CAI Han
作者单位:
郑州大学第一附属医院
The First Affiliated Hospital Of Zhengzhou University
关键词:
地佐辛；芬太尼；依托咪酯；肌阵挛
Dezocine; Fentanyl; Etomidate; Myoclonus
摘要:
摘要：目的 观察芬太尼伍用地佐辛对全麻诱导时依托咪酯致肌阵挛的影响。方法 ASA分级Ⅰ或Ⅱ级准备行全身麻醉手术的患者80例，根据麻醉诱导用药情况不同随机分为两组，每组40例：Ⅰ组，地佐辛0.1mg/kg、芬太尼3μg/kg、依托咪酯0.3mg/kg；Ⅱ组（对照），生理盐水5ml、芬太尼3μg/kg、依托咪酯0.3mg/kg；两组药分别在全麻诱导时按顺序静脉推注，其中芬太尼与依托咪酯均在5秒内注射完毕。观察肌阵挛的发生情况和严重程度，同时观察有无呛咳现象发生。结果 Ⅰ组肌阵挛的发生率(5.0％)小于Ⅱ组（52.5％）（P＜0.05），肌阵挛严重程度亦轻于Ⅱ组，且无呛咳现象发生。 结论 芬太尼复合依托咪酯麻醉诱导时使用地佐辛可减少肌阵挛的发生，且同时起到了抑制呛咳反应的作用。
Abstract:Objective To observe the effect of the combined use of fentanyl and dezocine on etomidate-induced myoclonus during anesthesia induction. Methods:A total of 80 ASA physical status Ⅰ or Ⅱpatients undergoing general anesthesia were assigned into two groups.Each group contains 40 patients.GroupⅠreceived dezocine 0.1mg/kg,fentanyl 3μg/kg,etomidate 0.3mg/kg.Group Ⅱ received normal saline 5ml,fentanyl 3μg/kg,etomidate 0.3mg/kg.All the drugs were intravenously injected sequentially.The fentanyl and etomidate should be injected less than 5 seconds.Then the occurrence and severity of myoclonus was observed and recorded in two minutes.At the same time the occurrence of bucking was observed. Results:The frequence and the intensity of myoclonus was significantly lower in group Ⅰ(5.0％)than in group Ⅱ(52.5％) (P<0.05)and with no occurrence of bucking. Conclusion:The use of dezocine during anesthesia induction can reduce the etomidate -induced myoclonus and at the same time reduce the occurrence of bucking that caused by fentanyl.

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