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胆管黏液腺癌临床病理学特点及预后分析（附13例报告）
Clinicopathological features and postoperative prognosis of mucinous cholangiocarcinoma in 13 cases

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DOI:
作者:
施洋，庞书杰，叶庆旺，张海斌，杨宁，杨广顺
Shi Yang, Pang Shujie, Ye Qingwang, Zhang Haibin, Yang Ning, Yang Guangshun
作者单位:
东方肝胆外科医院肝外五科，上海 200438； 苏州大学医学院，江苏苏州 215000； （所有作者的单位都为上海市东方肝胆外科医院肝外五科，其中叶庆旺为上海东方肝胆外科医院与苏州大学医学院联合培养。）
Department V of Surgery, Easten Hepatobiliary Surgery Hospital, Shanghai 200438, China； Suzhou University School of Medicine, Jiangsu 21500, China
关键词:
胆管黏液腺癌；预后；根治性切除；淋巴结转移
Mucinous cholangiocarcinoma; Prognosis; Radical resection; Lymph node metastasis
摘要:
目的 研究胆管黏液腺癌的临床病理学特征及预后特点。方法 回顾性分析我院2002年1月至2014年12月期间收治的13例胆管黏液腺癌患者的临床资料。结果 13例患者中男性8例（61.5％）、女性5例（38.5%），男女比例1:1.6。年龄35-74岁，平均年龄57.7岁，中位年龄60岁。其中5例行肝切除术， 5例行肝门部胆管癌根治术， 2例行胰十二指肠切除术，1例因肿瘤转移行姑息性T管引流。所有患者术后病理皆证实为胆管黏液腺癌，术后中位生存时间50.2个月。根据有无淋巴结转移将患者分为两组，通过Log-rank法比较两组预后有明显差异（P=0.005）。结论 胆管黏液腺癌的影像学表现符合其病理特征，预后可能优于普通胆管腺癌，淋巴结转移是影响手术预后的危险因素。
Objective To analyze clinical characteristics and prognosis of mucinous cholangiocarcinoma (MCC). Methods A retrospective study was made on clinical manifestations, operative procedures and postoperative prognosis in 13 cases of MCC. Results Among the 13 cases, 8(61.5%) were men and 5 (38.5%) were women, with a median age of 60 years old (range 35-74years). Hepatoectomy was performed in 5 cases, Hilar resection in 5 cases and Pancreaticoduodenectomy in 2 cases. External biliary drainage was carried out through a T-tube was done in 1 case. All patients are confirmed by pathological MCC, the median survival time after surgery was 54 months. According to lymph node metastasis patients were divided into two groups, there are significant differences in prognosis between the two groups (P = 0.005). Conclusions The imaging findings of MCC consistent with the pathological features of MCC, the postoperative prognosis of MCC may be better than ordinary cholangiocarcinoma, Lymph node metastasis as a significant prognostic factor.

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