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白细胞计数与非酒精性脂肪性肝病的相关性研究(重新投稿)
White blood cell count is associated with nonalcoholic fatty liver disease
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DOI:
作者:
黄小琳 徐佰慧 李勉 林琳 孙继超 李婧 毕宇芳 宁光
Huang Xiao-lin, Xu Bai-hui, Li Mian, Lin Lin, Sun Ji-chao, Li Jing, Bi Yu-fang, Ning Guang
作者单位:
上海交通大学医学院附属瑞金医院内分泌代谢病科,上海市内分泌代谢病临床医学中心,上海市内分泌代谢病研究所
Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Clinical center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic diseases, Shanghai 200025,China
关键词:
非酒精性脂肪性肝病;白细胞计数
nonalcoholic fatty liver disease; white blood cell count
摘要:
目的:探讨上海地区40岁及以上人群中正常范围内白细胞计数与非酒精性脂肪性肝病的相关性。方法:选取上海市嘉定社区40岁及以上居民1 914名为研究对象,针对每位居民进行问卷调查、体格检查、血常规及生化检查,所有居民均接受了腹部B型超声检查。在排除了其他肝脏疾病及过量饮酒后,按照腹部B型超声检查结果诊断非酒精性脂肪性肝病。结果:(1)总人群中非酒精性脂肪性肝病的患病率为25.8%,患有非酒精性脂肪性肝病者白细胞计数明显高于无非酒精性脂肪性肝病者(P<0.000 1)。(2)随着白细胞计数水平的增加,非酒精性脂肪性肝病的患病率逐渐增加(从白细胞计数的下三分位至上三分位,非酒精性脂肪性肝病的患病率依次为17.2%、25.0%、34.5%,趋势P值<0.000 1)。(3)Logistic多元回归分析显示,在校正多种混杂因素后,与白细胞计数水平位于下三分位者相比,白细胞计数水平位于上三分位者非酒精性脂肪性肝病的患病风险明显增高(OR=1.55,95%CI:1.11-2.14)。结论:上海地区40岁及以上人群中,正常范围内高水平的白细胞计数与非酒精性脂肪性肝病的患病风险显著独立相关。
Objective: White blood cell (WBC) count is a simple and global marker of inflammation for clinical practice. The present study aimed to determine the association between WBC count which was in normal range and the presence of nonalcoholic fatty liver disease (NAFLD). Method: A cross-sectional study with 1 914 subjects aged 40 years or older from Jiading district, Shanghai, was conducted. All participants received questionnaire survey, anthropometric measurements, blood routine and biochemical test. NAFLD was defined based on abdominal ultrasonographic findings after excluding subjects with known liver disease and excess alcohol consumption. Results: The total prevalence of NAFLD was 25.8%, the level of WBC count was significantly higher in subjects with NAFLD than those without NAFLD (P<0.000 1). (2) The percentage of NAFLD gradually increased in accordance with WBC count tertiles: as 17.2%, 25.0% and 34.5%, respectively (P for trend<0.000 1). (3) A fully adjusted multivariate logistic regression analysis revealed that compared with subjects in the lowest tertile of normal WBC count, the risk of NAFLD of those in the highest tertile was increased (OR=1.55, 95%CI: 1.11-2.14). Conclusion: Normal but higher level of WBC count was independently associated with the presence of NAFLD in subjects aged 40 years or older in Shanghai.
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