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丹蒌片改善急性高脂血症大鼠血脂紊乱的实验研究
The hypolipidaemic activity of danlou tablet extract in Triton WR-1339 induced hyperlipidaemic rats: A comparison with rosuvastatin
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DOI:
作者:
纪睿圳,俞诚虹,贺治青, 伍锋,王新,梁春,厉娜,吴宗贵
JI Ruizhen,YU Chenghong,HE Zhiqing,WU Feng,Wang Xin,Liang Chun,Li Nan,WU Zonggui
作者单位:
第二军医大学附属长征医院心内科 上海200003
Department of Cardiology,Changzheng Hospital,Second Military Medicial University,Shanghai 200003,China
关键词:
丹蒌片;高脂血症;调节血脂
Hyperlipidemia;Danlou tablet;Blood lipids regulation
摘要:
【摘要】目的:研究丹蒌片治痰为先法对实验性急性高脂血症大鼠血清胆固醇和甘油三脂的动态影响及其机制。方法:取健康成年雄性SD大鼠,48只随机分为6组:空白对照组、模型对照组、瑞舒伐他汀组、低剂量丹蒌片组、中剂量丹蒌片组和高剂量丹蒌片组,各组连续给药14天后,采用尾静脉注射Triton-WR1339加高脂喂养建立急性高脂血症大鼠模型,立即观察造模后48h内血脂指标动态变化、肝脏脂质水平及肝脏相关脂质代谢基因表达。结果:高剂量丹蒌片能显著抑制Triton引发的急性血清TC 和TG的升高作用(P<0.05),而瑞舒伐他汀不能快速发挥有效的降脂作用,低、中剂量丹蒌片组的降脂作用都明显不及高剂量组,其降脂作用存在明显剂量依赖性(P<0.05);高剂量丹蒌片组的肝脏脂质含量要明显低于模型对照组和他汀组(P<0.05);对于肝脏乙酰辅酶A羧化酶(ACC)和胆固醇7-羟化酶(CYP7A1)的表达,前者高剂量丹蒌片组明显低于模型对照组和他汀组(P<0.05),后者高剂量丹蒌片组明显高于他汀组(P<0.05)。结论:丹蒌片能有效地降低血浆胆固醇和甘油三酯水平,且不引起肝脏脂质沉积,其机制可能与增加肝脏CYP7A1表达和减少ACC合成有关。
Objective:We have studied method of Danlou tables’ dynamic effcet on serum cholesterol , triglyceride in experimental acute hyperlipidemia rats. Methods: 48 healthy adult male SD rats were randomly divided into 6 groups: blank control group, model control group, rosuvastatin group, low dose of Danlou tablet group, medial dose of Danlou tablet group, high dose of Danlou tablet group. After continuous administration of each therapy for 14 days ,rats were treated with tail intravenous injection of Triton WR-1339 at a dose of 200mg/kg in normal saline and received high fat diets,to build acute hyperlipidemia rat model,and observe dynamic change of blood lipid index within 48 hour after the model was established and levels of liver lipid and expression of relevant lipid metabolism genes. Result: administration of high dose Danlou tablet can significantly inhibit an acute rise in serum TC and TG caused by Triton-WR1339 (P<0.05),but rosuvastatin can not exert lipid-lowering effect fully. Lipid-lowering effect in low or medial dose Danlou tablet group were obviously less than high dose group, and its lipid-lowering effect is obviously dose dependent (P<0.05);Liver lipid levels in high dose Danlou tablet group was significantly lower than the model control group and the statin group (P<0.05);For expression of liver acetyl CoA carboxylase (ACC) and cholesterol 7 - hydroxylase (CYP7A1),the former in high dose Danlou tablet group was lower than that in model control group and the statin group (P<0.05),the latter in high dose Danlou tablet group was obviously higher than statin group (P < 0.05). Conclusion: Danlou tablet can effectively reduce both plasma cholesterol and triglyceride levels, but do not cause liver lipid deposition, and its mechanism may be related to the up-regulation of CYP7A1 and down-regulation of ACC in liver.
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