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异氟醚对大鼠条件性味觉厌恶记忆获取、巩固及再巩固的影响
The Influence of Isoflurane On Acquisition, Consolidation And Reconsolidation of Conditioned Taste Aversion Memory In Rats

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DOI:
作者:
王森森，庄蕾，于布为
WANG Sensen, ZHUANG Lei, YU Buwei
作者单位:
上海交通大学医学院附属瑞金医院
Department of Anesthesiology,Ruijin Hospital, Shanghai Jiaotong University School of Medicine
关键词:
异氟醚，条件性味觉厌恶，记忆获取，巩固，再巩固
Isoflurane, Conditioned taste aversion, Acquisition, Consolidation, Reconsolidation
摘要:
【摘要】目的：观察吸入麻醉药异氟醚对大鼠条件性味觉厌恶记忆的获取、巩固及再巩固三个不同阶段的影响。方法：将72只健康成年雄性Sprague-Dawley大鼠随机分为3组，即记忆获取组、记忆巩固组及记忆再巩固组，每组24只；每组均再分为2个亚组，即异氟醚暴露组及空氧混合气体暴露组，每亚组12只。所有大鼠均予以条件性味觉厌恶（CTA）训练使其对糖精钠水产生厌恶记忆。3组大鼠分别在条件性味觉厌恶记忆的获取、巩固及再巩固阶段予以异氟醚（1MAC, 2h）或空氧混合气体（70%Air+30%O2, 2h）暴露，训练后24、48及72h连续三次检测大鼠的糖水厌恶指数以观察异氟醚暴露对大鼠条件性味觉厌恶记忆不同阶段的影响。结果：记忆获取组中，测试期异氟醚组大鼠糖水厌恶指数较空氧混合气体组降低（p<0.05）。记忆巩固组中，大鼠接受异氟醚暴露后其测试期的糖水厌恶指数较对照组增高（p<0.05）。在记忆再巩固组中，测试期异氟醚组及对照组大鼠的糖水厌恶指数无显著差异（p>0.05）。结论：异氟醚可损害大鼠条件性味觉厌恶记忆的获取，并增强其巩固过程，但对其再巩固无显著影响。
【Abstract】 Objective: To investigate the influence of isoflurane on acquisition, consolidation and reconsolidation of the conditioned taste aversion (CTA) memory in rats. Methods: 72 male adult Sprague-Dawley rats were randomly divided into 3 groups (n=24): Acquisition Group, Consolidation Group and Reconsolidation Group. Each group was further divided into 2 subgroups (n=12): Isoflurane Exposure Subgroup and Air+O2 Exposure Subgroup. All rats formed aversion memory of saccharin sodium water through CTA training. In acquisition, consolidation, or reconsolidation stage during CTA training, rats in corresponding group were exposed to either Isoflurane or Air+O2, and their aversion index of saccharin sodium water was consecutively measured 24, 48 and 72 hours after training. Results: In Acquisition Group, the Isoflurane Exposure Subgroup showed lower aversion index of saccharin sodium water compared to the Air+O2 Exposure Subgroup (p<0.05). While in Consolidation Group, the Isoflurane Exposure Subgroup showed higher aversion index of saccharin sodium water compared to the Air+O2 Exposure Subgroup (p<0.05). In Reconsolidation Group, rats exposed to isoflurane or Air+O2 had similar aversion index of saccharin (p>0.05). Conclusion: Isoflurane could impair the acquisition of CTA, enhance the consolidation of CTA, but have no significant influence on the reconsolidation of CTA.

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