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SUMO4多态性与上海地区汉族人群2型糖尿病周围神经病变相关性分析
Relationship between SUMO4 gene 163A/G polymorphism and type 2 diabetic peripheral neuropathy in Han population of Shanghai
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DOI:
作者:
李璐,张蓉,王从容,贾伟平
LI Lu, ZHANG Rong, Wang Congrong, JIA Weiping
作者单位:
上海市糖尿病研究所 上海市糖尿病重点实验室 上海市糖尿病临床医学中心 上海交通大学附属第六人民医院内分泌代谢科
Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, China.
关键词:
小泛素样修饰蛋白4(SUMO4)基因;163 A/G多态性;糖尿病周围神经病变;2型糖尿病
Small ubiquitin-like modifier 4 (SUMO4) gene; 163A/G polymorphism; Diabetic peripheral neuropathy; Type 2 diabetes mellitus
摘要:
目的 探讨小泛素样修饰蛋白4(SUMO4)基因163A/G多态性与上海地区汉族人群2型糖尿病周围神经病变(DPN)的相关性。 方法 上海地区197例汉族2型糖尿病患者分为未合并周围神经病变组(DPN0,n=89)和合并周围神经病变组(DPN,n=108)。受试者均进行神经电生理检测,测定神经包括正中运动神经、正中感觉神经、尺运动神经、尺感觉神经、胫神经和腓肠神经。此外,计算传导速度、潜伏期和振幅的Z-score以综合评估外周神经功能,Z-score计算方法以传导速度为例,分别计算每根神经传导速度Z-score:(实测值-正常对照组均数)/正常对照组标准差,传导速度Z-score=∑所有神经Z-score/6。应用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)方法检测SUMO4基因163A/G多态性。 结果 检出多态基因型AA、GA和GG。基因型频率分布符合Hardy-Weinberg遗传平衡定律。DPN0组AA、GA、GG 3种基因型频率分别为42.7%、44.9%和12.4%;DPN组3种基因型频率分别为39.8%、47.2%和13.0%,DPN0组和DPN组A等位基因频率分别为65.2%和63.4%。DPN0组和DPN组基因型和等位基因频率无统计学差异(P > 0.05)。不同基因型亚组间各神经传导速度、潜伏期、振幅、传导速度Z-score、潜伏期Z-score、振幅Z-score、周围神经功能异常率及DPN患病率比较均无统计学差异(P > 0.05)。Logistic回归分析显示矫正年龄、性别、糖化血红蛋白和糖尿病病程后,DPN组与DPN0组SUMO4多态基因型及等位基因频率比较,差异仍无统计学意义(P > 0.05)。 结论 在上海地区汉族2型糖尿病人群中未发现SUMO4基因163A/G多态性与DPN有关。
Objective To explore the relationship between small ubiquitin-like modifier 4 (SUMO4) gene 163A/G polymorphism and type 2 diabetic peripheral neuropathy (DPN) in Han population of Shanghai. Methods One hundred and ninety seven Han ethnic patients in Shanghai with type 2 Diabetes (T2DM) were divided into non-DPN group (DPN0 group, n=89) and DPN group (DPN group, n=108). All participants underwent nerve conduction studies with median motor nerve, median sensory nerve, ulnar motor nerve, ulnar sensory nerve, tibial nerve and sural nerve tested. The composite Z-scores for conduction velocity (CV), amplitude and latency were calculated as well in order to globally evaluate the peripheral neuropathy function. For each individual, every CV value was transformed into a Z-score using the formula: Z-score = (individual value of patient - mean value of control group)/ SD of control group. A composite CV Z-score was then calculated as (∑Z-scores of all nerves)/6. The composite Z-scores for amplitude and latency were calculated similarly. PCR-RFLP was used to detect the polymorphism of SUMO4 gene 163A/G. Results Three genotypes (AA, GA and GG) were detected. SUMO4 gene 163A/G was consistent with Hardy-Weinberg equilibrium law. The frequencies of AA, GA and GG genotypes in DPN0 group were 42.7%, 44.9% and 12.4%. The frequencies in DPN group were 39.8%, 47.2% and 13.0%. A allele frequencies in DPN0 and DPN group were 65.2% and 63.4%, respectively. There were no significant differences in genotypic or allelic frequencies between DPN0 group and DPN group (P > 0.05). CV, amplitude and latency of each nerve, Z-scores of CV, amplitude and latency, the prevalence of abnormal peripheral nerve and DPN were all not significantly different among there genotypic groups (P > 0.05). Logistic regression analysis revealed that there were still no differences in genotypic or allelic frequencies between DPN0 group and DPN group after adjustment for age, sex, HbA1c and duration of diabetes (P > 0.05). Conclusion No correlation of the SUMO4 gene A/G polymorphism with type 2 diabetic peripheral neuropathy was found in Han population of Shanghai.
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