首页
期刊简介
编 委 会
期刊订阅
百年学会 医星璀璨
名院风范
学科风华
菁英风采
投稿须知
过刊浏览
联系我们
篇名
关键词
作者
作者单位
摘要
关键词
注册本刊作者
作者投稿查稿
专家远程审稿
编辑在线审稿
编务办公专区
主编办公专区
下载文档
《上海医学》审稿费代缴委托书
《上海医学》杂志2024年征订启事回执
《上海医学》期刊编审系统审稿专家使用手册
工作动态
03-05
《上海医学》杂志2024年度“春蕾杯”论文评比征文通知
06-14
创新驱动,培育人才—《上海医学》2021年度春蕾计划评审结果揭晓
01-21
《上海医学》期刊影响力指标和学科排名取得显著提升
01-20
《上海医学》恭祝大家新年快乐!
08-18
作废声明
联系方式
发行周期:
月刊
主管单位:
上海市卫生健康委员会
主办单位:
上海市医学会
编辑出版:
《上海医学》编辑部
联系地址:
上海市北京西路1623号
邮编:
200040
电话:
021-62178606
传真:
021-62178606
邮箱:
smasmj@shsma.org.cn
ISSN:
ISSN0253-9934
CN:
CN31-1366/R
收款账号:
1001255309008900719
账户名:
上海市医学会
开户行:
工商银行上海市静安寺支行
友情链接
上海市医学会
当前位置:首页 >
Netrin-1在经皮肾镜术后急性肾损伤患者血、尿中的表达与临床意义
Expression of serum and urinary netrin-1 of patients with acute kidney injury after percutaneous nephrolithotomy and its clinical significance
浏览(718) 下载(2)
DOI:
作者:
侯颉玢 张书玥 谌卫 彭泳涵 李凌 高小峰 郭志勇
HOU Hiebin, ZHANG Shuyue, CHEN Wei, PENG Yonghan, LI Ling, GAO Xiaofeng, GUO zhiyong.
作者单位:
海军军医大学长海医院肾内科(侯颉玢,谌卫, 郭志勇);海军军医大学学员旅(张书玥);海军军医大学长海医院泌尿外科(彭泳涵,李凌,高小峰)
Changhai Hospital,The Second Military Medical University, Shanghai
关键词:
肾结石;经皮肾镜术;急性肾损伤;Netrin-1
Kidney stone; Percutaneous nephrolithotomy; Acute kidney injury; Netrin-1
摘要:
目的 探讨肾结石患者术前血、尿netrin-水平与经皮肾镜术后急性肾损伤(AKI)的关系,并分析术后AKI发生的危险因素。方法 以2014年01月至2016年12月因患肾结石在长海医院泌尿外科行经皮肾镜术治疗的334例患者为研究对象。检测患者术前血、尿netrin-1含量及其他基本临床指标,分别比较其在术后AKI和非AKI患者间的水平差异。采用多因素logistic回归分析术后AKI发生的高危因素。结果 肾结石患者经皮肾镜术后AKI的发生率为14.7%。血清netrin-1与尿netrin-1/肌酐值在术后AKI患者的水平均显著性高于非AKI患者。血清netrin-1含量(OR=1.062,P=0.036)与糖尿病(OR=2.138,P=0.027)是术后AKI发生的独立危险因素。 结论 术前血、尿Netrin-1含量与泌尿系统结石经皮肾镜术后AKI的发生关系密切。术前血清netrin-1水平与糖尿病是术后AKI发生的独立危险因素。
Objective to investigate the correlations between the preoperative serum and urinary levels of netrin-1 and the incidence of acute kidney injury (AKI) after percutaneous nephrolithotomy, and to analyze the risk factors of postoperative AKI. Methods Clinial data of patients with nephrolithiasis treated by percutaneous nephrolithotomy (PCNL) from January 2014 to December 2016 in department of Urology of Changhai Hospital were analyzed. The serum and urinary netrin-1 concentration and other basic clinical indexes were measured before the operation, and the difference between the level of netrin-1 in AKI and non-AKI patients after operation was compared. Multivariate logistic regression was used to analyze the risk factors of postoperative AKI. Results the incidence of AKI in patients with nephrolithiasis after PCNL was 14.7%. The level of serum netrin-1 and urinary netrin-1/creatinine in patients with AKI were significantly higher than those in non-AKI patients. The concentration of serum netrin-1 (OR=1.062, P=0.036) and diabetes mellitus (OR=2.138, P=0.027) were independent risk factors for postoperative AKI. Conclusion The preoperative serum and urinary levels of netrin-1 were significantly associated with the incidence of AKI after PCNL. The preoperative serum level of netrin-1 and diabetes are independent risk factors for the incidence of postoperative AKI.
点击下载DOC全文