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42第5期
如皋衰老队列中抑郁症状和轻度认知功能障碍的关联分析
Association study of depression symptoms and cognition impairment in Rugao Longevity and ageing study
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DOI:
作者:
侯卓然,王久存,王笑峰
HOU Zhuoran, WANG Jiucun, WANG Xiaofeng
作者单位:
200438 上海,复旦大学生命科学学院现代人类学教育部重点实验室(侯卓然, 王久存,王笑峰)
Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
关键词:
抑郁症状,认知功能受损,老年人
Depression symptoms, Cognition impairment, older population
摘要:
目的 为了在中国人群中探究老年人抑郁症状和认知功能受损的关系。方法 我们采用如皋衰老队列的1526名老年参与者,收集其人口统计学数据,对其抑郁症状我们采用了老年抑郁量表(Geriatric Depression Scale, GDS-15)进行测量,对其认知能力我们采用了简易精神状态量表(Mini–Mental State Examination,MMSE)进行测量。我们使用线性回归对GDS评分和MMSE评分进行关联分析。此外,我们还根据受教育程度对人群进行分组,使用logistic回归计算抑郁症状对认知功能受损的OR值。模型均进行协变量的矫正。结果 在原始模型中,我们发现GDS评分和MMSE评分均显著相关(p<0.001, β=-0.67),提示抑郁症状越重,认知能力越差,结果在矫正各协变量以后仍然显著。我们进一步按照受教育程度分组进行分析,在原始模型中,文盲组和小学组中老年人的抑郁症状显著增加老年人患认知功能受损的风险(文盲组:OR=2.22, 95%置信区间为1.45-3.48,p<0.001; 小学组:OR=1.83, 95%置信区间为1.08-3.07,p=0.024)。总体来看,这个结果也是显著的(OR=2.20,95%置信区间为1.67-2.93,p<0.001)。以上结果在矫正协变量后也保持一致。这些结果表明老年人中有抑郁症状的具有更高风险患认知功能受损。结论 老年人中出现抑郁症状显著增加老年人认知功能障碍的风险,在临床上对老年人抑郁症状的干预可能有助于预防和减缓老年人的认知能力下降的症状。
Objective: In order to explore the relationship between depression symptoms and cognition impairment in the elderly in China.Methods: The data is from the Rugao Longevity and Ageing Study (RuLAS), including 1526 older people. We collected the demographic data and used Geriatric Depression Scale (GDS-15) to access the depression symptoms and Mini–Mental State Examination (MMSE) to evaluate the cognition in the participants. We used linear regression to analyze the relationship between GDS scores and MMSE score. Moreover, based on the grouping of education levels, we used logistic regression calculate the odds ratios for depression symptoms to cognition impairment. All the results were adjusted by adding demographic covariates.Results: In the crude model, we found that the GDS scores were significantly associated with MMSE scores (p<0.001, β= -0.67), indicating that those with worse depression symptoms also had bad cognitive function. This result was still significant after adjusting covariates. Moreover, we further analyzed the data according to the levels of education. In the crude model, depression symptoms in older adults in the illiterate and primary school groups significantly increase the risk of cognition impairment (illiterate group: OR=2.22, 95% CI,1.45-3.48, p<0.001; primary school group: OR=1.83, 95% CI, 1.08-3.07, p=0.024). The overall result was also significant ( OR=2.20,95%CI, 1.67-2.93, p<0.001). These results did not change after adjusting covariates. All the results above showed that the depression symptoms in the Chinese older people significantly increase the risk of having cognition impairment. Conclusion: Depression symptoms in the elderly significantly increase the risk of cognition impairment in the elderly, and clinical interventions in depression symptoms in the elderly may help prevent and slow down the symptoms of cognitive decline in the elderly.
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